HOW ABOUT SEXUALLY DIFFERENTIATING FACTORS
OTHER THAN ESTROGEN?
Commentary on Fitch & Denenberg on Sex-Brain

Abstract

Whereas the evidence of estrogen-mediated sexual differentiation is irrefutable, the strength of this evidence may have inadvertantly prejudiced researchers against looking to other factors in the differentiation process. Consideration of the role of progesterone, as well as additional non-steroidal ovarian secretions, may provide additional insights into mechanisms of sexual differentiation. Further consideration of non-ovarian factors, such as the potential role of genes involved in peripheral sexual differentiation and the influence of changes in afferent input, would be equally valuable in elucidating the mechanisms of sexual differentiation.

Keywords

References

• Beyer, C. and Feder, H.H. (1987) Sex steroids and afferent input: Their roles in brain sexual differentiation. Ann. Rev. Physiol. 49:349-364.
• Denenberg, V.H., Fitch, R.H., Schrott, L.M., Cowell, P.E. and Waters, N.S. (1991) Corpus callosum interactive effects of testosterone and handling in the rat. Behavioral Neuroscience 105: 562-566.
• Fitch, R.H. and Denenberg, V.H. (1995) A Role for Ovarian Hormones in Sexual Differentiation of the Brain. PSYCOLOQUY 6(5) sex-brain.1.fitch.
• Hendricks, S.E. (1992) Role of estrogens and progestins in the development of female sexual behavior potential. In: Handbook of Behavioral Neurobiology, vol. 11: Sexual Differentiation, A.A. Gerall, J. Moltz, and I.L. Ward (Eds.) Plenum Press, New York. p. 129-155.
• Hidalgo, A., Barami, K., Iversen, K. and Goldman, S.A. (1995) Estrogens and non-estrogenic ovarian influences combine to promote the recruitment and decrease the turnover of new neurons in the adult female canary brain. J. Neurobiol. 27: 470-487.
• Mani, S.K., Allen, J.M.C., Clark, J.H., Blaustein, J.D. and O'Malley, B.W. (1994) Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science 265: 1246-1249.
• McCarthy, M.M. (1994) Molecular Aspects of Sexual Differentiation of the Rodent Brain. Psychoneuroendocrinology 19:415-427.
• McCarthy, M.M. (1995) Functional significance of steroid modulation of GABAergic neurotransmission: Analysis at the behavioral, cellular and molecular levels. Horm. Behav. 29:131-140.
• Pappas, C.T.E., Diamond, M.C. and Johnson, R.E. (1979) Morphological changes in the cerebral cortex of rats with altered levels of ovarian hormones. Behavioral and Neural Biology 26: 298-310.
• Reisert, I. and Pilgram, C. (1991) Sexual differentiation of monoaminergic neurons - genetic or epigenetic? Trends Neurosci. 14: 468-473.
• Rucklidge, J. (1995) Incorporating estrogen's masculinizing role. PSYCOLOQUY 6(18).sex-brain.2.rucklidge.
• Ward, I.L. (1992) Sexual behavior: The product of perinatal hormonal and prepubertal social factors. In: Handbook of Behavioral Neurobiology, vol. 11: Sexual Differentiation, A.A. Gerall, J. Moltz, and I.L. Ward (Eds.) Plenum Press, New York. p. 129-155.