EXCITOTOXIC ASPECTS OF LITHIUM NEUROTOXICITY
Target Article by West on Lithium-Toxicity

Abstract

The potential importance of excitotoxic mechanisms in understanding lithium neurotoxicity is underscored by clinical and laboratory data which are reviewed here. A variety of different animal models of neurotoxicity are discussed as potential strategies for exploring excitotoxic aspects of lithium. Clinical research strategies suggested by the excitotoxic concept are also discussed, including use of neuroprotective drug treatment to prevent lithium induced irreversible brain damage.

Keywords

References

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