INCORPORATING ESTROGEN'S MASCULINIZING ROLE
Commentary on Fitch & Denenberg on Sex-Brain

Abstract

The role of estrogen in differentiating the sexes may not be as clearly defined as Fitch & Denenberg would have us believe. Although their presentation of the feminizing role for estrogen was intriguing, I question whether it can be so easily categorized and wonder where the research on estrogen's masculinizing role fits into their model.

Keywords

References

• Breedlove, S.M. (1994). Sexual differentiation of the human nervous system. Annual Review of Psychology, 45, 465-488.
• Dohler, K.D., Hines, M., Coquelin, A., Davis, F., Shryne, J.E. & Gorski, R.A. (1982). Pre- and postnatal influence of diethylstilbestrol on differentiation of the sexually dimorphic nucleus in the preoptic area of the female rat brain. Neuroscience Letters, 4, 361-365.
• Ehrhardt, A.A., Meyer-Bahlburg, H.F.L., Rosen, L.R., Feldman, J.F., Veridiano, N.P., Zimmerman, I. & McEwen, B.S. (1985). Sexual orientation after prenatal exposure to exogeneous estrogen. Archives of Sexual Behavior, 14, 57-77.
• Fitch, R. H. & Denenberg, V.H. (1995). A Role for Ovarian Hormones in Sexual Differentiation of the Brain. PSYCOLOQUY 6(5) sex-brain.1.fitch.
• Hendricks, S.E. (1969). Influence of neonatally administered hormones and early gonadectomy on rats' sexual behavior. Journal of Comparative Physiology and Psychology, 69, 408-413.
• Hines, M. (1982). Prenatal gonadal hormones and sex differences in human behavior. Psychological Bulletin, 92, 56-80.
• Hines, M., Alsum, P., Roy, M., Gorski, R.A. & Goy, R.W. (1987). Estrogenic contributions to sexual differentiation in the female guinea pig: Influences of diethylstilbestrol and tamoxifen on neural, behavioral and ovarian development. Hormones and Behavior, 21, 402-417.
• Hines, M. & Collaer, M.L. (1991). Gonadal hormones and sexual differentiation of human behavior: Developments from research on endocrine syndromes and studies of brain structure. Annual Review of Sex Research, 4, 1-48.
• Hines, M. & Shipley, C. (1984). Prenatal exposure to diethylstilbestrol (DES) and the development of sexually dimorphic cognitive abilities and cerebral lateralization. Developmental Psychology, 20, 81-94.
• MacLusky, N.J., Naftolin, F. & Goldman-Rakic, P.S. (1986). Estrogen formation and binding in the cerebral cortex of the developing rhesus monkey. Proceedings of the National Academy of Science, 83, 513-516.
• MacLusky, N.J. & Naftolin, F. (1981). Sexual differentiation of the central nervous system. Science, 211, 1294-1303.
• Meyer-Bahlburg, H.F., Feldman, J.F., Cohen, P. & Ehrhardt, A.A. (1988). Perinatal factors in the development of gender-related play behavior: Sex hormones versus pregnancy complications. Psychiatry, 51, 260-271.
• Mullins, R.F. & Levine, S. (1968). Hormonal determinants during infancy of adult sexual behavior in the male rat. Physiology and Behavior, 3, 339- 343.
• Reinisch, J.M., Ziemba-Davis, D.M. & Sanders, S.A. (1991). Hormonal contributions to sexually dimorphic behavioral development in humans. Special issue: Neuroendocrine effects on brain development and cognition. Psychoneuroendocrinology, 16, 213-278.
• Schachter, S.C. (1994). Handedness in women with intrauterine exposure to diethylstilbestrol. Neuropsychologia, 32, 619-623.
• Whalen, R.E. & Nadler, R.D. (1963). Suppression of the development of female mating behavior by estradiol administration in infancy. Science, 141, 273-274.